Supporting drug efficacy and safety studies with advanced pharmacology tools

● EU-compliant Animal Facility

● ECG, echocardiography, and small animal surgery equipment

● Size Exclusion Chromatography-Static Light Scattering (SEC-SLS) for determination of absolute molecular weights of proteins, polymers, and other macromolecules (OMNISEC RESOLVE and OMNISEC REVEAL by Malvern Panalytical)

● Leica STELLARIS, SP8, SP8 MP Super-Resolution STED/FLIM/FCS microscope

● High-resolution respirometry Oxygraph-2k with multi-sensor modules

● MicroBeta TriLux multi-detector plate counter for liquid scintillation and luminescence measurements

● BD FACS Melody cell sorter system

● Sable System Promethion Core® Line (16 cages) metabolic and behavioral phenotyping system

● Sable System Promethion Core® Line (16 cages) metabolic and behavioral phenotyping system

State-of-the art tools for structural biology

Protein Expression and purification Facility

800 MHz NMR system (solution state HCN-probe, solid state probe)

600 MHz NMR system (solution state HCN-probe, cryoprobe)

Maldi-TOF

Isotermal titration calorimetry (ITC)

Surface plasmon resonance (SPR)

Grating-coupled interferometry (GCI)

Microscale thermophoresis

Light scattering and Langmuir–Blodgett  for nanoparticles and aggregates

Polymer processing instruments: Electrospinning SpinBox, Spincoater

Fully equipped lab-space for synthesis and analytics

–          Hoods with inert gas and set of routine equipment for synthesis and sample processing
synthesis

–          Parallel synthesis stations and dry blocks

–          Batch and flow electrochemistry equipment

–          Batch and flow photochemistry equipment

–          Microwave synthesizers

• High presure reactors
  • Preparative flash chromatography systems with UV and ELSD detectors
  • Preparative HPLC systems, with MS and UV detectors
  • Set of preparative chiral HPLC columns

–          Glovebox for handling of air/moisture sensitive materials

–          Solvent purification station

–          10,000+ in house  chemical reagents and building blocks

–          Analytical LC/SQ-MS, GC/MS

–          Preparative Flash Chromatography

–      Computational Tools: access to computational cluster, ChemDraw, MestReNova

NMR systems : 400MHz (autosampler, solution state BB-probe), 300MHz (autosampler)

Powder and single crystal X-ray diffractometers

Synapt GII q-ToF HRMS system with UPLC front-end

IT-ToF HRMS system with UPLC front-end

Quattro Micro, Xevo TQ-S, micro-TQ-S tandem mass-spectrometers, UPLC front-end with bioanalytical sample preparation equipment set

Analytical HPLC-systems with UV, PDA, fluorescence, ELS detectors

GC-based microanalysis systems for C,H, N, S

FT-IR spectrometer with spectra library

GC/FID and GC/MS systems.

Electron paramagnetic resonance (EPR)

Infrared spectroscopy (IR)

Polarimeter

Reactors and Work-Up Stations:

–          63 L glass-lined rector
–          20 L double jacketed glass reactor
          –          1,2 and 25 L hastelloy high pressure reactors
          –          temperature controlers
–          Parr pressure reactors (25L, 1.2L)

Evaporation Systems:

–          20 L rotary evaporator
–          VTA Wiped-film Evaporator, up to 5 kg/hour

Filtration Systems:

–          Centrifuge (14 L, 2500rpm)
–          PTFE Pressure Filters (40L, 2L)