Drug Discovery
Synthetic Hit to Lead and Lead optimization
In silico design and virtual HTS
Natural products as leads
Fragment based lead discovery
Structural biology: X-ray and NMR
Biochemical and biophysical assays
Recombinant protein production
Mode of action studies
Preclinical Drug Development
Animal Models of Neurological and Neurodegenerative Diseases
Istroke models
Traumatic Brain Injury (TBI) Models
Neuropathic Pain Models
Inflammatory Pain Models
Acute Pain Models
Epilepsy Models
Depression Models
Cognition and Dementia Models
Anxiety Models
Experimental Models of Cardiovascular Diseases
Organ bath experiments
Isolated heart according to Langendorff
Measurement of blood pressure
Echocardiographic Assessment of Cardiac Anatomy and Function
Assessment of Antiarrhythmic activity
Myocardial infarction in vivo in rats
Experimental atherosclerosis in mice
DMPK and safety
Pharmacokinetic Assays
Single and Repeated Dose Safety (Toxicity) Studies
In vitro ADMET studies
Plasma protein binding
Chemical, microsomal, plasma and blood stability, identification of metabolites
Solubility and LogP/LogD assays
Manufacturing technologies
Route scouting
Route optimization
Kg-scale synthesis
Impurity profiling
Polymorphism testing
GMP stability testing, method validation and QC analyses
Synthetic chemistry
Synthesis of reference compounds
Asymmetric synthesis, separation of enantiomers
Electrochemistry: batch and flow
Photochemistry: batch and flow
Fluorochemistry
Selenium chemistry
Nucleotide chemistry
C-H activation
Analytical Chemistry
Mass Spectrometry services
HRMS systems Synapt GII q-ToF, IT-ToF with UHPLC front-end
MS/MS analyses with UHPLC front-end
MALDI-TOF MS/MS
Chromatography
HPLC/UHPLC Systems with UV, PDA, MS, fluorescence, and ELSD detectors
Gas Chromatography with FID, TCD, and MS detectors
Microanalysis
C, H, N, S elemental analysis
NMR Facility
300MHz, 400MHz, and 600MHz solution state spectroscopy equipment for detailed molecular analysis 1D; 2D, H, C, F, N, B, Si
800MHz NMR system for solid state NMR studies
X-ray Diffractometry
Single crystal and powder X-ray diffractometry systems
Expert-Designed Compounds
Explore our catalogue of expertly designed compounds available for synthesis and purchase. Developed by leading scientists at the Latvian Institute of Organic Synthesis, our high-quality compounds support research and innovation across pharmaceuticals, biotechnology, and material sciences.
Our partners share their experience with us
Birthplace of 18 Original Drugs
and over 100 innovative technologies
Comprehensive support
across all stages of drug discovery to preclinical development
240+ Scientific Staff
Including 58 Principal Scientists
Global Network
55 industry partners in 2024. Main partners from the EU, UK, USA, and Switzerland
Long-Term Partnerships
75% of customers have maintained partnerships with LIOS for over 5 years
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