Animal Models of Neurological and Neurodegenerative Diseases
Istroke models
Traumatic Brain Injury (TBI) Models
Neuropathic Pain Models
Inflammatory Pain Models
Acute Pain Models
Epilepsy Models
Depression Models
Cognition and Dementia Models
Anxiety Models

Experimental Models of Cardiovascular Diseases
Organ bath experiments
Isolated heart according to Langendorff
Measurement of blood pressure
Echocardiographic Assessment of Cardiac Anatomy and Function
Assessment of Antiarrhythmic activity
Myocardial infarction in vivo in rats
Experimental atherosclerosis in mice

DMPK and safety
Pharmacokinetic Assays
Single and Repeated Dose Safety (Toxicity) Studies

In vitro ADMET studies
Plasma protein binding
Chemical, microsomal, plasma and blood stability, identification of metabolites
Solubility and LogP/LogD assays

Route scouting

Route optimization

Kg-scale synthesis

Impurity profiling

Polymorphism testing

GMP stability testing, method validation and QC analyses

Synthesis of reference compounds

Asymmetric synthesis, separation of enantiomers

Electrochemistry: batch and flow

Photochemistry: batch and flow

Fluorochemistry

Selenium chemistry

Nucleotide chemistry

C-H activation

Mass Spectrometry services

HRMS systems Synapt GII q-ToF, IT-ToF with UHPLC front-end

MS/MS analyses with UHPLC front-end

MALDI-TOF MS/MS

Chromatography

HPLC/UHPLC Systems with UV, PDA, MS, fluorescence, and ELSD detectors

Gas Chromatography with FID, TCD, and MS detectors

Microanalysis

C, H, N, S elemental analysis

NMR Facility 

300MHz, 400MHz, and 600MHz solution state spectroscopy equipment for detailed molecular analysis 1D;  2D, H, C, F, N, B, Si 

800MHz NMR system for solid state NMR studies

X-ray Diffractometry

Single crystal and powder X-ray diffractometry systems

Explore our catalogue of expertly designed compounds available for synthesis and purchase. Developed by leading scientists at the Latvian Institute of Organic Synthesis, our high-quality compounds support research and innovation across pharmaceuticals, biotechnology, and material sciences.

See our catalogue

Supporting drug efficacy and safety studies with advanced pharmacology tools

● EU-compliant Animal Facility

● ECG, echocardiography, and small animal surgery equipment

● Size Exclusion Chromatography-Static Light Scattering (SEC-SLS) for determination of absolute molecular weights of proteins, polymers, and other macromolecules (OMNISEC RESOLVE and OMNISEC REVEAL by Malvern Panalytical)

● Leica STELLARIS, SP8, SP8 MP Super-Resolution STED/FLIM/FCS microscope

● High-resolution respirometry Oxygraph-2k with multi-sensor modules

● MicroBeta TriLux multi-detector plate counter for liquid scintillation and luminescence measurements

● BD FACS Melody cell sorter system

● Sable System Promethion Core® Line (16 cages) metabolic and behavioral phenotyping system

● Sable System Promethion Core® Line (16 cages) metabolic and behavioral phenotyping system

State-of-the art tools for structural biology

Protein Expression and purification Facility

800 MHz NMR system (solution state HCN-probe, solid state probe)

600 MHz NMR system (solution state HCN-probe, cryoprobe)

Maldi-TOF

Isotermal titration calorimetry (ITC)

Surface plasmon resonance (SPR)

Grating-coupled interferometry (GCI)

Microscale thermophoresis

Light scattering and Langmuir–Blodgett  for nanoparticles and aggregates

Polymer processing instruments: Electrospinning SpinBox, Spincoater

Fully equipped lab-space for synthesis and analytics

-          Hoods with inert gas and set of routine equipment for synthesis and sample processing
synthesis

-          Parallel synthesis stations and dry blocks

-          Batch and flow electrochemistry equipment

-          Batch and flow photochemistry equipment

-          Microwave synthesizers

• High presure reactors
  • Preparative flash chromatography systems with UV and ELSD detectors
  • Preparative HPLC systems, with MS and UV detectors
  • Set of preparative chiral HPLC columns

-          Glovebox for handling of air/moisture sensitive materials

-          Solvent purification station

-          10,000+ in house  chemical reagents and building blocks

-          Analytical LC/SQ-MS, GC/MS

-          Preparative Flash Chromatography

-      Computational Tools: access to computational cluster, ChemDraw, MestReNova

NMR systems : 400MHz (autosampler, solution state BB-probe), 300MHz (autosampler)

Powder and single crystal X-ray diffractometers

Synapt GII q-ToF HRMS system with UPLC front-end

IT-ToF HRMS system with UPLC front-end

Quattro Micro, Xevo TQ-S, micro-TQ-S tandem mass-spectrometers, UPLC front-end with bioanalytical sample preparation equipment set

Analytical HPLC-systems with UV, PDA, fluorescence, ELS detectors

GC-based microanalysis systems for C,H, N, S

FT-IR spectrometer with spectra library

GC/FID and GC/MS systems.

Electron paramagnetic resonance (EPR)

Infrared spectroscopy (IR)

Polarimeter

Reactors and Work-Up Stations:

-          63 L glass-lined rector
-          20 L double jacketed glass reactor
          -          1,2 and 25 L hastelloy high pressure reactors
          -          temperature controlers
-          Parr pressure reactors (25L, 1.2L)

Evaporation Systems:

-          20 L rotary evaporator
-          VTA Wiped-film Evaporator, up to 5 kg/hour

Filtration Systems:

-          Centrifuge (14 L, 2500rpm)
-          PTFE Pressure Filters (40L, 2L)